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June 1, 2000British Journal of PharmacologyOpen Access

Electrophysiological effects of endothelin‐1 and their relationship to contraction in rat renal arterial smooth muscle

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Population

Endothelium-denuded arteries and freshly isolated smooth muscle cells from the main branch of the renal…

Design

Preclinical

Authors

LBLuisa C. BettsMansfield University RKRoland Z. KozlowskiMansfield University

Discussion

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Implication

May guide ETA-targeted vasoconstriction therapies; leaves open human translation from animal data.

Structured PICO

P

Population

Endothelium-denuded arteries and freshly isolated smooth muscle cells from the main branch of the renal artery of rats

I

Intervention

Endothelin-1 (ET-1)

O

Outcome

Electrophysiological effects (membrane potential, K+ channel activity) and arterial constrictionsurrogate

ET-1 induces renal artery constriction through ETA receptor-mediated inhibition of potassium channels, leading to depolarization and calcium influx.

Cite This Study

Betts et al. (2000) studied this question.

synapsesocial.com/papers/6a70a0cafe4101aa97e03fee https://doi.org/10.1038/sj.bjp.0703377

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Endothelin induces a nonselective cation current in vascular smooth muscle cells.1991 · 65 citations
2ET<sub>A</sub>receptor‐mediated responses to endothelin‐1 and big endothelin‐1 in the rat kidney1994 · 62 citations
3Renal actions of endothelin peptides1993 · 24 citations
4Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.1986 · 459 citations
5Down-Regulation of Na<sup>+</sup>/K<sup>+</sup>ATPase Activity by Human Parvovirus B19 Capsid Protein VP12013 · 8,699 citations