Population
Rat isolated mesenteric resistance vessels (MRVs) and cultured aortic smooth muscle cells
Comparison
Endothelin-1 (ET-1) vs Other agonists including norepinephrine…
Design
Preclinical
Authors
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Refutes ET-1 as solely an endogenous voltage-sensitive Ca2+ channel activator in animal vessels; leaves open its precise role and therapeutic targeting in humans.
ET-1 functions as a full contractile agonist that induces Ca2+-antagonist insensitive Ca2+ influx, membrane depolarization, and intracellular Ca2+ release, rather than acting solely as an endogenous voltage-sensitive Ca2+ channel activator.
Wallnöfer et al. (1989) studied this question.
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