Population
Endothelium-denuded rat isolated aorta
Comparison
Calcium entry blockers and calcium readdition vs Absence of calcium entry blockers, or…
Design
Preclinical
Authors
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Does not support altering calcium channel blocker use; leaves open non-L-type calcium pathways in endothelin signaling for study.
Contractions induced by endothelin-1 and its analogues in rat aorta depend partially on extracellular calcium, but likely not through direct activation of L-type calcium channels.
Topouzis et al. (1989) studied this question.
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