Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1998AJP Lung Cellular and Molecular Physiology

Inhibition of voltage-gated K+current in rat intrapulmonary arterial myocytes by endothelin-1

View Full Paper
Ask AI
Bookmark
Share

Population

Rat intrapulmonary arterial smooth muscle cells

Design

Preclinical

Authors

LSLarissa A. ShimodaJohns Hopkins UniversityJSJ. T. SylvesterBioZyme (United States)JSJames S.K. ShamJohns Hopkins University

Discussion

Loading...

Member takes

Implication

ET-1 Kv inhibition in animal pulmonary smooth muscle leaves open human relevance; further translational studies needed before clinical consideration.

Structured PICO

P
Population
Rat intrapulmonary arterial smooth muscle cells
I
Intervention
Endothelin-1 (10^-10 to 10^-7 M)
O
Outcome
Membrane depolarization and inhibition of voltage-dependent K+ currentsurrogate

Endothelin-1 modulates pulmonary vascular reactivity by depolarizing pulmonary arterial smooth muscle through the inhibition of Kv current via the phospholipase C-protein kinase C pathway.

Cite This Study

Shimoda et al. (1998) studied this question.

synapsesocial.com/papers/6a195beec05413006f5838c7https://doi.org/10.1152/ajplung.1998.274.5.l842
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein kinase C inhibits delayed rectifier K+ current in rabbit vascular smooth muscle cells1996 · 80 citations
  2. 2Endothelin receptor subtypes in human versus rabbit pulmonary arteries1994 · 123 citations
  3. 3Outward currents in rabbit pulmonary artery cells dissociated with a new technique1991 · 114 citations
  4. 4Tyrosine phosphorylation of the Kv1.3 potassium channel1996 · 173 citations
  5. 5Voltage-Gated K + Currents Regulate Resting Membrane Potential and [Ca 2+ ] i in Pulmonary Arterial Myocytes1995 · 295 citations