Key result
Application of endothelin-1 (1-100 nmol/l) inhibited the inward rectifier potassium current and increased the activity of nonspecific cation channels in cultured endothelial cells.
Population
Cultured bovine pulmonary arterial endothelial cells and cultured human umbilical vein endothelial cells
Design
Preclinical
Authors
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Endothelin-1 effects on endothelial ion channels remain preclinical; leaves open their contribution to vascular tone in vivo.
Endothelin-1 modulates ion channels in endothelial cells, potentially increasing calcium influx and promoting the release of endothelium-derived factors.
Zhang et al. (2008) studied this question. Endothelin-1 (ET-1) was evaluated on Inward rectifier potassium current and nonspecific cation current activity. Application of endothelin-1 (1-100 nmol/l) inhibited the inward rectifier potassium current and increased the activity of nonspecific cation channels in cultured endothelial cells.
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