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Does endothelin-1 modulate renal hemodynamics and tubular sodium reabsorption in isolated perfused rat kidneys?
Does endothelin-1 modulate renal hemodynamics and tubular sodium reabsorption in isolated perfused rat kidneys?
Endothelin-1 exerts natriuretic and diuretic effects despite reducing glomerular filtration rate in isolated perfused rat kidneys, suggesting direct modulation of tubular sodium reabsorption.
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ET-1's tubular effects in rat kidneys support direct natriuresis despite lower GFR; leaves open human translation.
In an attempt to clarify the pathophysiological role of endothelin (ET), a novel vasoconstrictor peptide, we administered this peptide into the medium of isolated perfused rat kidney (IPK). ET increased renal vascular resistance by 53%, and reduced inulin clearance by 29% in IPK at a higher concentration of 500 PM. However, fractional excretion of sodium and urine flow rate were increased by 160% and 109%, respectively. These findings suggest that ET modulates the tubular sodium reabsorption as well as the renal hemodynamics.
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Nitta et al. (1989) studied this question.
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