Key result
IV endothelin raises BP and cuts glomerular blood flow ~70% by preferentially constricting larger preglomerular vessels.
Why the study?
Does endothelin affect renal microcirculation and systemic blood pressure in a rat model?
Population
Split hydronephrotic rat kidney model
Comparison
Endothelin administered intravenously or locally vs Baseline or co-administration with leukotriene…
Design
Preclinical
Authors
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Rat endothelin data should not guide human therapy; leaves open leukotriene mediation of preglomerular constriction for further study.
Does endothelin affect renal microcirculation and systemic blood pressure in a rat model?
Endothelin acts as a potent vasoconstrictor in the renal microcirculation, with intravenous effects likely mediated by leukotrienes on larger vessels and local effects acting directly on smaller vessels.
Fretschner et al. (1991) studied Split hydronephrotic rat kidney model. Endothelin (ET) was evaluated on Glomerular blood flow and vessel diameters. Intravenously applied endothelin increased systemic blood pressure and decreased glomerular blood flow by 70%, preferentially constricting larger preglomerular vessels.
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