Key result
Endothelin infusion produced a dose-related increase in renal vascular resistance and a significant, dose-dependent decrease in glomerular filtration rate in the rabbit isolated perfused kidney.
Why the study?
Does endothelin infusion increase renal vascular resistance and decrease glomerular filtration rate in the rabbit isolated perfused kidney?
Population
Rabbit isolated perfused kidney (IPK)
Comparison
Endothelin infusion (10(-11)-10(-9) M) vs Angiotensin II and noradrenaline infusions
Design
Preclinical
Authors
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Supports further renal physiology research; should not influence clinical decisions.
Does endothelin infusion increase renal vascular resistance and decrease glomerular filtration rate in the rabbit isolated perfused kidney?
Endothelin is a potent preglomerular vasoconstrictor that increases renal vascular resistance and decreases glomerular filtration rate in the isolated rabbit kidney.
Cairns et al. (1989) studied this question. Endothelin vs. Angiotensin II and noradrenaline was evaluated on Renal vascular resistance (RVR) and glomerular filtration rate (GFR). Endothelin infusion produced a dose-related increase in renal vascular resistance and a significant, dose-dependent decrease in glomerular filtration rate in the rabbit isolated perfused kidney.
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