Key result
Age was associated with decreased active renin levels in both normal and hypertensive subjects, while inactive renin decreased with age only in hypertensive patients.
Why the study?
Does age affect active and inactive plasma renin levels in normal subjects and patients with essential hypertension before and after furosemide stimulation?
Population
41 normal subjects and 54 patients with essential hypertension (total n=95)
Comparison
Acute stimulation with furosemide and ambulation vs Baseline state and comparison between normal…
Design
Cross-sectional
Follow-up
Acute (following stimulation)
Authors
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Age-associated renin changes should not alter practice; leaves open mechanistic and outcome implications for age-specific hypertension research.
Observational (n=95)
Does age affect active and inactive plasma renin levels in normal subjects and patients with essential hypertension before and after furosemide stimulation?
Age differentially affects inactive plasma renin levels in normal subjects compared to patients with essential hypertension, while active renin decreases with age in both groups.
Nakamaru et al. (1981) conducted an observational in Essential hypertension (n=95). Age was evaluated on Levels of active and trypsin-activatable inactive plasma renin. Age was associated with decreased active renin levels in both normal and hypertensive subjects, while inactive renin decreased with age only in hypertensive patients.
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