What question did this study set out to answer?

To evaluate dynamic changes in active and inactive renin concentrations and determine which form of renin is selectively released by the kidney in essential and renovascular hypertension.

January 1, 1981HypertensionOpen Access

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension.

View Full Paper

Ask AI

Bookmark

Why the study?

How do active and inactive renin concentrations respond to physiological stimuli (sodium depletion and upright tilting) in patients with essential and renovascular hypertension?

Population

26 patients with hypertension

Comparison

Sodium depletion and upright tilting vs Baseline and intra-patient comparison

Design

Cohort

Authors

WAWataru AoiKyoto Prefectural University YDYutaka DoiUniversity of Miyazaki SSShinji SetoLiverpool Hospital

Discussion

Member takes

Implication

Renin dynamics in hypertension should not yet change practice; leaves open mechanisms of active-inactive renin conversion in renovascular disease.

Key Points

To evaluate dynamic changes in active and inactive renin concentrations and determine which form of renin is selectively released by the kidney in essential and renovascular hypertension.
Assessed plasma active and inactive renin concentrations before and after dietary sodium depletion in 21 essential hypertensive patients (15 with normal and 6 with low plasma renin activity).
Measured active and inactive renin levels across the renal vein of affected and non-affected kidneys, inferior vena cava, and femoral artery following upright tilting in patients with unilateral renovascular hypertension.
In essential hypertension with normal plasma renin activity (N=15), sodium depletion triggered a significant rise in active renin concentration (p < 0.01) and a decrease in the percentage of inactive renin (p < 0.01), with inactive renin increasing in 8 patients (p < 0.01) and remaining unchanged in 7.
In unilateral renovascular hypertension, active renin concentration in the affected renal vein was significantly higher than in the non-affected renal vein and inferior vena cava (p < 0.02), whereas inactive renin was significantly lower (p < 0.02).

Structured PICO

How do active and inactive renin concentrations respond to physiological stimuli (sodium depletion and upright tilting) in patients with essential and renovascular hypertension?

Population

26 patients with hypertension (15 with essential hypertension and normal plasma renin activity, 6 with essential hypertension and low plasma renin activity, and 5 with unilateral renal hypertension)

Intervention

Sodium depletion (for essential hypertension patients) and upright tilting (for unilateral renal hypertension patients)

Comparator

Baseline (pre-intervention) and intra-patient comparison (non-affected kidney and inferior vena cava)

Outcome

Active and inactive renin concentrationssurrogate

The study demonstrates complex dynamic responses of renin, suggesting that the ischemic kidney releases active renin which may subsequently become inactive, and may also activate inactive renin.

Cite This Study

Aoi et al. (1981) studied this question.

synapsesocial.com/papers/6a83c545f4298de60b3c2be1 https://doi.org/10.1161/01.hyp.3.1.126

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Renin dynamics in hypertension should not yet change practice; leaves open mechanisms of active-inactive renin conversion in renovascular disease.

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider