Key result
Ischemic kidneys in unilateral renal artery stenosis show lower inactive renin in venous versus arterial blood.
Why the study?
Does the ischemic kidney activate circulating inactive renin in patients with unilateral renal artery stenosis?
Population
42 patients, comprising 22 with Essential Hypertension and 20 with Unilateral Renal Artery Stenosis.
Comparison
Acute diuretic stimulation with furosemide 40 mg… vs Comparison between renal venous and arterial…
Design
Cross-sectional
Authors
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No immediate practice change in renovascular hypertension; leaves open mechanistic role of inactive renin activation and needs prospective validation.
Observational (n=42)
Does the ischemic kidney activate circulating inactive renin in patients with unilateral renal artery stenosis?
p-value: p=<0.005
The ischemic kidney in patients with unilateral renal artery stenosis not only releases active renin but also activates circulating inactive renin in vivo.
Glorioso et al. (1982) conducted an observational in Essential Hypertension and Unilateral Renal Artery Stenosis (n=42). Ischemic kidney (Unilateral Renal Artery Stenosis) vs. Non-ischemic kidney (Essential Hypertension or contralateral kidney) was evaluated on Venous-arterial difference in active and inactive renin levels (p=<0.005). The ischemic kidney in patients with unilateral renal artery stenosis activates circulating inactive renin, showing significantly lower inactive renin in renal venous versus arterial blood (P<0.005).
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