Key result
Acute renal perfusion pressure reduction fails to induce active renin release in long-established moderate hypertension.
Why the study?
Does acute reduction of renal perfusion pressure alter active and inactive renin levels in patients with essential hypertension?
Population
n=7 total: 5 patients with long established moderate hypertension, 1 normotensive patient, and 1 recent…
Design
Case_series
Follow-up
Acute (up to 30 minutes)
Authors
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No change to hypertension management indicated; leaves open baroreceptor desensitization in long-standing essential hypertension.
Does acute reduction of renal perfusion pressure alter active and inactive renin levels in patients with essential hypertension?
Long-standing essential hypertension may reduce the sensitivity of baroreceptors involved in renin release, blunting the normal renin response to acute reductions in renal perfusion pressure.
Glorioso et al. (1982) studied Essential hypertension (n=7). Acute reduction of renal perfusion pressure via balloon catheter vs. Baseline was evaluated on Arterial and renal venous active and inactive renin levels. Acute reduction of renal perfusion pressure via balloon catheter failed to induce the expected release of active renin in patients with long-established moderate hypertension.
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