Why the study?
Does renal arterial pressure govern the release of renin in rats with unilateral renal hypertension?
Population
Rats with unilateral renal hypertension produced by constricting the aorta just above the ostium of the left…
Design
Preclinical
Follow-up
2 weeks or more
Authors
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Renal arterial pressure may govern acute renin release in this rat model; leaves open translation to human renovascular hypertension.
Does renal arterial pressure govern the release of renin in rats with unilateral renal hypertension?
In a rat model of unilateral renal hypertension, increased renin-angiotensin system activity is limited to the acute stage of low renal arterial pressure, indicating that renal arterial pressure governs renin release.
Koletsky et al. (1967) studied this question.
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