Why the study?
Does the renin-angiotensin system drive the pathogenesis of severe hypertension in a rat model of aortic coarctation?
Population
Rats with severe hypertension induced by occluding the aorta between the origins of the renal arteries.
Comparison
Excision of the kidney distal to the ligature at… vs Nonnephrectomized rats with severe hypertension…
Design
Preclinical
Follow-up
Up to 10 days
Authors
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Supports renin as causal in this model; leaves open translation to human renovascular hypertension.
Does the renin-angiotensin system drive the pathogenesis of severe hypertension in a rat model of aortic coarctation?
This preclinical study demonstrates that severe hypertension following aortic coarctation is driven by a humoral factor (renin) produced by the kidney rather than purely mechanical resistance.
Carretero et al. (1971) studied this question.
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