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December 1, 1976American Journal of Physiology-Legacy Content

Central antihypertensive effects of inhibitors of the renin-angiotensin system in rats

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Why the study?

Does central administration of [Sar1, IIe8]angiotensin II reduce mean arterial pressure in rats with aortic coarctation?

Population

Rats made hypertensive by aortic coarctation (occluding the aorta between the renal arteries)

Comparison

[Sar1, IIe8]angiotensin II administered… vs Peripheral administration of [Sar1…

Design

Preclinical

Authors

SCSweet CsJCJM ColumboSGS L Gaul

Discussion

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Implication

Central angiotensin II antagonism may be more potent in this rat model; leaves open CNS mechanisms and clinical translation in human hypertension.

Structured PICO

Does central administration of [Sar1, IIe8]angiotensin II reduce mean arterial pressure in rats with aortic coarctation?

P
Population
Rats made hypertensive by aortic coarctation (occluding the aorta between the renal arteries)
I
Intervention
[Sar1, IIe8]angiotensin II (angiotensin II antagonist) administered centrally via intracerebroventricular (icv) injection (10-100 mug)
C
Comparator
Peripheral administration of [Sar1, IIe8]angiotensin II (100 mug intra-arterial bolus or intravenous infusion)
O
Outcome
Mean arterial pressure (MAP)surrogate

Central administration of an angiotensin II antagonist lowers blood pressure more effectively than peripheral administration in a rat model of aortic coarctation, suggesting a central nervous system role for angiotensin II in this hypertension model.

Cite This Study

Cs et al. (1976) studied this question.

synapsesocial.com/papers/6a8a6d9c2a1069eaeccbf4efhttps://doi.org/10.1152/ajplegacy.1976.231.6.1794
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of the central pressor action of angiotensin II in conscious rats1984 · 30 citations
  2. 2Effect of Administration of Sar1-Ala8-Angiotensin II during the Development and Maintenance of Renal Hypertension in the Rat1978 · 14 citations
  3. 3Central nervous system action of angiotensin during onset of renal hypertension in awake rats1984 · 21 citations
  4. 4Central site for pressor action of blood-borne angiotensin in rat1980 · 39 citations
  5. 5ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION PRODUCED BY UNILATERAL RENAL ARTERY CONSTRICTION IN THE RAT1976 · 1 citations