Key result
The central pressor effect of blood-borne angiotensin in rats was attenuated by intraventricular saralasin and abolished by lesions of the anteroventral third ventricle.
Population
Conscious rats, including a subset with chronic electrolytic lesions of the anteroventral third ventricle
Comparison
Intracarotid infusion of angiotensin II, with or… vs Intra-aortic infusion of angiotensin II
Design
Preclinical
Authors
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Identifies periventricular structures mediating angiotensin effects in rats; leaves open translation to human hypertension mechanisms.
Periventricular structures surrounding the third ventricle mediate the central component of the pressor action of blood-borne angiotensin in rats.
Fink et al. (1980) studied this question. Intracarotid vs intra-aortic infusions of angiotensin II was evaluated on Difference in pressor responses to intracarotid and intra-aortic infusions of angiotensin II (delta c-a). The central pressor effect of blood-borne angiotensin in rats was attenuated by intraventricular saralasin and abolished by lesions of the anteroventral third ventricle.
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