Contribution of the Sympathetic Nervous System to the Centrally-Induced Pressor Action of Angiotensin Ii in Rats
Key result
Intracerebroventricular Angiotensin II stimulates the sympathetic nervous system to drive initial pressor action in rats.
Population
Normotensive and spontaneously hypertensive rats
Comparison
Intracerebroventricular injection of Angiotensin… vs Control rats receiving i.c.v. Angiotensin II…
Design
Preclinical
Authors
Discussion
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Implication
May implicate sympathetic activation in rat central Ang II pressor effects; leaves open translation to human hypertension mechanisms.
Structured PICO
P
Population
Normotensive and spontaneously hypertensive rats.
I
Intervention
Intracerebroventricular (i.c.v.) injection of Angiotensin II, combined with sympathetic nervous system inhibition (phentolamine, reserpine, or guanethidine)
C
Comparator
Control rats receiving i.c.v. Angiotensin II without sympathetic inhibition
O
Outcome
Blood pressure response and plasma noradrenaline concentrationssurrogate
In rats, the central pressor effects of Angiotensin II involve sympathetic nervous system stimulation, which is functionally important for the initial phase of the pressor response.
Cite This Study
Mann et al. (1982) studied Normotensive and spontaneously hypertensive rats. Intracerebroventricular Angiotensin II vs. control rats was evaluated on Blood pressure response and plasma noradrenaline concentrations. Intracerebroventricular injection of Angiotensin II stimulated the sympathetic nervous system, which may be functionally important for the initial phase of the central pressor action in rats.