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September 1, 1984AJP Regulatory Integrative and Comparative Physiology

Mechanism of pressor effects by angiotensin in the nucleus tractus solitarius of rats

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Population

Urethan-anesthetized rats (intact and hypophysectomized)

Comparison

Microinjection of angiotensin II into the… vs Preblockade ANG II responses or intact controls

Design

Preclinical

Authors

RCR. Michael CastoFlorida State UniversityMPM. Ian PhillipsCalifornia Institute of Technology

Discussion

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Implication

Highlights sympathetic mediation of NTS ANG II pressor effects in animals; leaves open human relevance and clinical translation.

Structured PICO

P
Population
Urethan-anesthetized rats (intact and hypophysectomized)
I
Intervention
Microinjection of angiotensin II (50-500 ng) into the nucleus tractus solitarius (NTS), with or without hexamethonium (20 mg/kg iv) or vasopressin antagonist d(CH2)5Tyr(Me)AVP (1 microgram iv)
C
Comparator
Preblockade ANG II responses or intact controls
O
Outcome
Change in mean arterial pressure (MAP)surrogate

The pressor response to angiotensin II in the NTS is mediated by descending sympathetic fibers rather than pituitary vasopressin release.

Cite This Study

Casto et al. (1984) studied this question.

synapsesocial.com/papers/6a882ab186ac178e8f608baehttps://doi.org/10.1152/ajpregu.1984.247.3.r575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CONTRIBUTION OF THE SYMPATHETIC NERVOUS SYSTEM TO THE CENTRALLY-INDUCED PRESSOR ACTION OF ANGIOTENSIN II IN RATS1982 · 9 citations
  2. 2Effect of angiotensin II in ventrolateral medulla of spontaneously hypertensive rats1991 · 103 citations
  3. 3Angiotensin II attenuates baroreflexes at nucleus tractus solitarius of rats1986 · 148 citations
  4. 4Neurohumoral contributions to chronic angiotensin-induced hypertension1986 · 35 citations
  5. 5Enhanced responses to pressor stimuli by intracerebroventricular infusions of angiotensin II in conscious rats.1986 · 2 citations