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January 1, 1986Japanese Circulation Journal-english EditionOpen Access

Enhanced responses to pressor stimuli by intracerebroventricular infusions of angiotensin II in conscious rats.

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Why the study?

Does intracerebroventricular infusion of angiotensin II alter pressor responsiveness to intravenous angiotensin II and norepinephrine in conscious rats?

Population

Conscious rats

Comparison

Intracerebroventricular infusion of a subpressor… vs Before IVT infusion (baseline)

Design

Preclinical

Authors

HMHIDEYO MATSUOGunma UniversitySIShûichi IchikawaToyohashi University of TechnologyTSTetsuo SakamakiGunma University

Discussion

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Implication

Supports central RAS modulation of pressor responses in rats; leaves open translation to human hypertension mechanisms.

Structured PICO

Does intracerebroventricular infusion of angiotensin II alter pressor responsiveness to intravenous angiotensin II and norepinephrine in conscious rats?

P
Population
Conscious rats
I
Intervention
Intracerebroventricular (IVT) infusion of a subpressor dose (3 ng/kg/min) or pressor dose (50 ng/kg/min) of angiotensin II
C
Comparator
Before IVT infusion (baseline)
O
Outcome
Pressor responses to intravenous (IV) infusions of angiotensin II and IV bolus injections of norepinephrinesurrogate

Activation of the brain renin-angiotensin system via intracerebroventricular infusion of a subpressor dose of angiotensin II enhances pressor responses to systemic vasoconstrictors in conscious rats.

Cite This Study

MATSUO et al. (1986) studied this question.

synapsesocial.com/papers/6a735a75668da3c6682c29bchttps://doi.org/10.1253/jcj.50.270
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central angiotensin II-induced responses in spontaneously hypertensive rats1977 · 90 citations
  2. 2Pressor responses to vasopressin in rabbits with 3-day renal artery stenosis1981 · 17 citations
  3. 3Potentiation of the effects of noradrenaline and of sympathetic stimulation of the perfused rat caudal artery by angiotensin1970 · 31 citations
  4. 4Pressor responses to norepinephrine in rabbits with 3-day and 30-day renal artery stenosis. The role of angiotensin II.1978 · 44 citations
  5. 5Circulatory effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs. Studies on the development of an experimental model of hypertension.1979 · 14 citations