Key result
Peripheral sympathectomy resulted in a prolonged latency for pressor response to intracerebroventricular angiotensin II, while adrenalectomy did not alter drinking or pressor responses.
Population
Unrestrained, unanesthetized rats
Comparison
Intracerebroventricular injections of 50 and 500… vs Baseline (before treatment)
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic mediation of central Ang II effects in rats; leaves open relevance to human cardiovascular regulation.
Sympathetic neural activation, rather than the adrenals, mediates the early pressor response to central angiotensin II in rats.
Falcón et al. (1978) studied this question. Intracerebroventricular injections of angiotensin II vs. Before treatment was evaluated on Water drinking and blood pressure responses. Peripheral sympathectomy resulted in a prolonged latency for pressor response to intracerebroventricular angiotensin II, while adrenalectomy did not alter drinking or pressor responses.
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