Why the study?
Does intraventricular infusion of a subpressor dose of angiotensin II increase pressor responsiveness to intravenous angiotensin II in pentobarbital anesthetized rats?
Does intraventricular infusion of a subpressor dose of angiotensin II increase pressor responsiveness to intravenous angiotensin II in pentobarbital anesthetized rats?
The central iso-renin angiotensin system plays an important role in potentiating pressor responsiveness to peripheral angiotensin II, independent of changes in endogenous plasma renin activity.
Central angiotensin II may modulate peripheral pressor sensitivity in rats; leaves open translation to conscious models or human hypertension.
The effect of intraventricular (IVT) infusion of a subpressor dose (6.25 or 12.5ng/kg/min) of angiotensin II (AII) on the pressor responses to intravenous (IV) infusion of All were studied in pentobarbital anesthetized rats. This study was undertaken to determine whether the central iso-renin angiotensin system alters pressor responsiveness to IV infused AII. Pressor responses to IV infusion of AII were potentiated by concurrent IVT infusion of a subpressor dose of AII. IVT pressor doses of AII decreased plasma renin activity, however, IVT subpressor doses of AII did not.These results suggest that the central iso-renin angiotensin system plays an important role in pressor responsiveness to IV AII and that the potentiation of IV AII is not related to decreases in endogenous AII as a result of IVT administered AII.
No takes yet. Share an insight, caveat, or question.
HIDEYO MATSUO (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: