Interactions between angiotensin II and α‐adrenoceptor agonists mediating pressor responses in the pithed rat

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Population

Pithed rat model

Design

Preclinical

Authors

Discussion

Hypothesis-generating for angiotensin-adrenergic vascular interactions in rats; leaves open clinical relevance pending higher-species validation.

Population

Pithed rat model

Intervention

Teprotide (1 mg/kg or 10 mg/kg), angiotensin II infusion (50 ng/kg/min), saralasin (4 mcg/kg/min), and flurbiprofen (5 mg/kg)

Outcome

Diastolic blood pressure and pressor responses to alpha 1- and alpha 2-adrenoceptor agonistssurrogate

Endogenous angiotensin II facilitates alpha-adrenoceptor-mediated pressor responses independently of basal blood pressure in a pithed rat model.

Grant et al. (1988) studied this question.

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Hypothesis-generating for angiotensin-adrenergic vascular interactions in rats; leaves open clinical relevance pending higher-species validation.