Why the study?
Do angiotensin II, III, and IV exert direct positive chronotropic effects in pithed rats and isolated rat atria?
Do angiotensin II, III, and IV exert direct positive chronotropic effects in pithed rats and isolated rat atria?
Angiotensin II and III exert direct positive chronotropic effects via AT1 receptors, independent of the adrenergic system.
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Supports direct AT1-mediated chronotropy in rodent models; leaves open human relevance and arrhythmia implications.
Li et al. (1996) studied this question.
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