Key result
Angiotensin II elicits an AT2 receptor-mediated increase in neuronal firing rate, an effect involving generation of lipoxygenase metabolites of arachidonic acid and activation of PP-2A.
Population
Cultured neurons from newborn rat hypothalamus and brain stem
Comparison
Superfusion of Angiotensin II plus losartan vs Losartan alone, or addition of AT2 receptor…
Design
Preclinical
Authors
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AT2-mediated neuronal effects remain preclinical; leaves open translation to human cardiovascular autonomic control.
Angiotensin II increases neuronal firing rate in rat brain neurons via AT2 receptors, involving lipoxygenase metabolites and PP-2A activation.
Zhu et al. (2001) studied this question. Angiotensin II vs. Losartan alone / Baseline was evaluated on Neuronal firing rate. Angiotensin II elicits an AT2 receptor-mediated increase in neuronal firing rate, an effect involving generation of lipoxygenase metabolites of arachidonic acid and activation of PP-2A.
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