Population
Neurons cultured from the brainstem and a hypothalamic block of newborn Sprague Dawley rats
Comparison
Angiotensin II (100 nM) application vs Control solution (HBG) or untreated neurons
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for Ang II-AT2 neuronal signaling and leaves mechanism open for human validation.
Angiotensin II stimulates neuronal delayed-rectifier potassium current via an AT2 receptor-mediated pathway involving phospholipase A2, arachidonic acid, and lipoxygenase metabolites.
Zhu et al. (1998) studied this question.
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