September 1, 1999Journal of Neurophysiology

Angiotensin II Decreases Neuronal Delayed Rectifier Potassium Current: Role of Calcium/Calmodulin-Dependent Protein Kinase II

View Full Paper

Ask AI

Bookmark

Population

Neurons cultured from the hypothalamus and brain stem of newborn rats

Design

Preclinical

Authors

MZMingyan ZhuUniversity of South China CGCraig H. GelbandUniversity of Iowa PPPhilip PosnerFlorida State University

Discussion

Member takes

Implication

Elucidates CaMKII role in Ang II neuronal Kv modulation; leaves open relevance to in vivo autonomic cardiovascular control.

Structured PICO

Population

Neurons cultured from the hypothalamus and brain stem of newborn rats

Intervention

Angiotensin II (Ang II) application, with or without selective inhibition of calmodulin, CaM KII, or PKC, and intracellular application of activated CaM KIIalpha

Outcome

Neuronal delayed rectifier (Kv) current and CaM KII activitysurrogate

Angiotensin II decreases neuronal delayed rectifier potassium current via a Ca2+/calmodulin/CaM KII pathway in addition to PKC.

Cite This Study

Zhu et al. (1999) studied this question.

synapsesocial.com/papers/6a70e05ef44fa9f079de9b37 https://doi.org/10.1152/jn.1999.82.3.1560

View Full Paper

Ask AI

Bookmark

Angiotensin II Decreases Neuronal Delayed Rectifier Potassium Current: Role of Calcium/Calmodulin-Dependent Protein Kinase II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Decreases Neuronal Delayed Rectifier Potassium Current: Role of Calcium/Calmodulin-Dependent Protein Kinase II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider