Key result
Angiotensin II-induced increases in neuronal firing rate in cultured rat neurons involve activation of both protein kinase C and calcium/calmodulin-dependent kinase II.
Population
Neurons in primary culture from newborn rat hypothalamus and brain stem
Design
Preclinical
Authors
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Identifies PKC and CaMKII as mediators of Ang II effects in rat neurons; leaves open their viability as targets in human hypertension.
The chronotropic action of Angiotensin II in neurons involves activation of both PKC and CaMKII, suggesting these enzymes are potential targets for manipulating central actions of Ang II.
Sun et al. (2002) studied this question. Angiotensin II vs. Inhibitors (U73122, calphostin C, KN-93) was evaluated on Neuronal firing rate. Angiotensin II-induced increases in neuronal firing rate in cultured rat neurons involve activation of both protein kinase C and calcium/calmodulin-dependent kinase II.
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