Key result
Angiotensin II caused a sixfold increase in neuronal firing rate in spontaneously hypertensive rat neurons compared to a threefold increase in Wistar-Kyoto rat neurons, mediated by PI3-kinase.
A PI3-kinase signaling pathway may be responsible for the enhanced chronotropic effect produced by Angiotensin II in neurons from spontaneously hypertensive rats.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for PI3-kinase in hypertension-related neuronal excitability; leaves open clinical relevance pending human data.
Sun et al. (2003) studied Hypertension. Angiotensin II vs. WKY rat neurons was evaluated on Neuronal firing rate. Angiotensin II caused a sixfold increase in neuronal firing rate in spontaneously hypertensive rat neurons compared to a threefold increase in Wistar-Kyoto rat neurons, mediated by PI3-kinase.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: