Key result
Intrarenal infusion of PKC inhibitors staurosporine or chelerythrine attenuated ANG II-induced renal vasoconstriction by a maximum of 60-70% in both hypertensive and normotensive rats.
Population
8-wk-old anesthetized spontaneously hypertensive rats and Wistar-Kyoto control rats pretreated with…
Comparison
Intrarenal infusion of PKC inhibitors and/or AT1… vs ANG II injection without PKC inhibitors; WKY vs…
Design
Preclinical
Authors
Loading...
Should not yet change hypertension practice; leaves open human translation of PKC-mediated renal effects.
The PKC system is a major intracellular signaling pathway coupled to the AT1 receptor in renal resistance vessels, and its activation by ANG II is similar in both hypertensive and normotensive young rats.
Ruan et al. (1996) studied Hypertension. PKC inhibitors (staurosporine or chelerythrine) vs. Angiotensin II alone was evaluated on Reduction of renal blood flow. Intrarenal infusion of PKC inhibitors staurosporine or chelerythrine attenuated ANG II-induced renal vasoconstriction by a maximum of 60-70% in both hypertensive and normotensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: