September 1, 1997Hypertension

Angiotensin II–Induced Phosphorylation of the AT ₁ Receptor From Rat Brain Neurons

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Population

Neuronal cultures of Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) brains

Design

Preclinical

Authors

HYHong YangKunming Medical University DLDi LuCentral Hospital of Zibo MRMohan K. RaizadaPreventive Cardiology

Discussion

Member takes

Implication

Does not support clinical translation; leaves open whether this mechanism operates in human hypertension.

Structured PICO

Population

Neuronal cultures of Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) brains

Intervention

Angiotensin II (Ang II) and MAP kinase kinase inhibitor PD98059

Outcome

AT1 receptor phosphorylation and 125I-[Sar1-Ile8]-Ang II binding abilitysurrogate

Angiotensin II stimulates phosphorylation of the neuronal AT1 receptor via a MAP kinase-dependent mechanism, resulting in loss of receptor binding activity.

Cite This Study

Yang et al. (1997) studied this question.

synapsesocial.com/papers/6a831a0a292d2964071f2b7f https://doi.org/10.1161/01.hyp.30.3.351

View Full Paper

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Angiotensin II–Induced Phosphorylation of the AT ₁ Receptor From Rat Brain Neurons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II–Induced Phosphorylation of the AT ₁ Receptor From Rat Brain Neurons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider