Population
Neurons cultured from neonatal rat hypothalamus and brainstem
Design
Preclinical
Authors
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Cautions against clinical extrapolation from neonatal rat neurons; leaves open AT1/AT2 opposition in human MAP kinase signaling.
Angiotensin II type 1 and type 2 receptors exert opposing modulatory effects on MAP kinase (Erk1 and Erk2) activities in neonatal rat neurons.
Huang et al. (1996) studied this question.
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