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September 1, 1999Molecular Endocrinology

Signals from the AT2 (Angiotensin Type 2) Receptor of Angiotensin II Inhibit p21ras and Activate MAPK (Mitogen-Activated Protein Kinase) to Induce Morphological Neuronal Differentiation in NG108–15 Cells

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Key result

Stimulation of AT2 receptors by Angiotensin II in NG108-15 cells induces neuronal morphological differentiation via inhibition of p21ras and an essential increase in MAPK activity.

Population

NG108-15 neuronal cell line and stably transfected NG108-15 cell line expressing the dominant-negative…

Design

Preclinical

Authors

LGLouis GendronLLLiette LaflammeNRNathalie Rivard

Discussion

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Overview

Extends AT2 signaling insights in neuronal models; hypothesis-generating and leaves open cardiovascular translation.

Structured PICO

P
Population
In vitro study using the neuronal cell line NG108-15 to investigate intracellular mediators of AT2 receptor-induced morphological differentiation.
I
Intervention
Angiotensin II (Ang II) stimulation and MEK inhibitor PD98059 (10 microM and 50 microM)
O
Outcome
Neurite outgrowth and intracellular signaling (p21ras inhibition, MAPK activation)surrogate

AT2 receptor-induced neuronal differentiation in NG108-15 cells involves both the inhibition of p21ras and the activation of MAPK.

Cite This Study

Gendron et al. (1999) studied Neuronal morphological differentiation (in vitro). Angiotensin II (AT2 receptor stimulation) was evaluated on Neurite outgrowth and MAPK activity. Stimulation of AT2 receptors by Angiotensin II in NG108-15 cells induces neuronal morphological differentiation via inhibition of p21ras and an essential increase in MAPK activity.

synapsesocial.com/papers/6a6b7ec3425eb3a8efb38d5dhttps://doi.org/10.1210/mend.13.9.0344
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