Population
Nondifferentiated and dibutyryl cAMP-differentiated NG108-15 cells
Comparison
Angiotensin II (100 nM) for 3 days vs Untreated cells or cells treated with AT1/AT2…
Design
Preclinical
Follow-up
3 days
Authors
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AT1/AT2 cross-talk in neuronal differentiation is hypothesis-generating; leaves open relevance to human neuroregeneration or angiotensin-targeted therapies.
Angiotensin II promotes neuronal differentiation through AT2 receptors and inhibits it through AT1 receptors, demonstrating negative cross-talk between the two receptor types.
Laflamme et al. (1996) studied this question.
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