February 1, 2003Journal of Biological ChemistryOpen Access

Cyclic AMP-independent Involvement of Rap1/B-Raf in the Angiotensin II AT2 Receptor Signaling Pathway in NG108-15 Cells

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Population

Neuronal cell line NG108-15

Comparison

Angiotensin II treatment, RapN17 and Rap1GAP… vs Untreated/control cells

Design

Preclinical

Authors

LGLouis GendronUniversité de Sherbrooke JOJean-François OlignyHôpital du Saint-Sacrement MPMarcel D. PayetUniversité de Sherbrooke

Discussion

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Implication

No immediate clinical implications from this cell model; leaves open therapeutic relevance of AT2 signaling in neuronal differentiation.

Structured PICO

Population

Neuronal cell line NG108-15

Intervention

Angiotensin II (Ang II) treatment, RapN17 and Rap1GAP transfection, and treatment with stimulators or inhibitors of the cAMP pathway (dibutyryl cAMP, forskolin, H-89, Rp-8-Br-cAMP-S)

Comparator

Untreated/control cells

Outcome

Activation of Rap1/B-Raf complex, p42/p44(mapk) phosphorylation, and morphological differentiation (neurite outgrowth)surrogate

The study demonstrates that Angiotensin II AT2 receptor activation induces neuronal differentiation via a cAMP-independent Rap1/B-Raf and p42/p44(mapk) signaling pathway.

Cite This Study

Gendron et al. (2003) studied this question.

synapsesocial.com/papers/6a70fb0f75498292b70a7792 https://doi.org/10.1074/jbc.m202446200

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Cyclic AMP-independent Involvement of Rap1/B-Raf in the Angiotensin II AT2 Receptor Signaling Pathway in NG108-15 Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cyclic AMP-independent Involvement of Rap1/B-Raf in the Angiotensin II AT2 Receptor Signaling Pathway in NG108-15 Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider