Key result
Treatment of mesencephalic precursor neurospheres with angiotensin II (100 nm) induced a ~400% increase in the generation of dopaminergic neurons, mediated by AT2 receptors.
Why the study?
Does angiotensin II increase the generation of dopaminergic neurons from mesencephalic precursors?
Population
Proliferating neurospheres of mesencephalic precursors
Comparison
Angiotensin II during the differentiation period vs Control and co-treatment with AT1 antagonist ZD…
Design
Preclinical
Authors
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Hypothesis-generating for AT2-targeted dopaminergic neurogenesis; leaves open translation to in vivo models or clinical use.
Does angiotensin II increase the generation of dopaminergic neurons from mesencephalic precursors?
Effect estimate: about 400% increase
Angiotensin II increases the differentiation of mesencephalic precursors into dopaminergic neurons via AT2 receptors, suggesting a potential strategy for generating cells for transplantation in Parkinson's disease.
Rodríguez‐Pallares et al. (2004) studied Parkinson's disease. Angiotensin II was evaluated on Generation of dopaminergic neurons (about 400% increase). Treatment of mesencephalic precursor neurospheres with angiotensin II (100 nm) induced a ~400% increase in the generation of dopaminergic neurons, mediated by AT2 receptors.
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