Population
Neurons cultured from newborn rat hypothalamus and brainstem
Comparison
Angiotensin II and AT2 receptor ligand CGP-42112A vs Control / antagonists
Design
Preclinical
Follow-up
30 min to 24 h
Authors
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Does not support clinical translation; leaves open AT2-Gi-PP2A signaling in central cardiovascular neurons for mechanistic follow-up.
Angiotensin II stimulates PP2A activity in rat hypothalamic and brainstem neurons via AT2 receptors and a Gi protein.
Huang et al. (1995) studied this question.
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