Why the study?
How signals from activated angiotensin type-2 receptors (AT2R) mediate inhibition of sodium ion reabsorption in renal proximal tubule cells was unknown.
Population
Normal 4- and 10-week-old Wistar-Kyoto rats and 4- and 10-week-old spontaneously hypertensive rats
Comparison
Compound-21 with or without calyculin A across rat strains and age groups
Design
Animal experimental study
Authors
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Should not yet change practice; leaves open whether PP2A restoration can rescue AT2R natriuresis in human hypertension.
AT2 receptor-mediated natriuresis requires PP2A activation and recruitment in normal rats, a mechanism that is defective in spontaneously hypertensive rats.
Kemp et al. (2021) studied this question.
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