December 1, 1989Journal of UOEHOpen Access

Inhibition of Renal Sympathetic Nerve Activity of Anesthetized Rats by Intracerebroventricular Administration of Angiotensin II

View Full Paper

Ask AI

Bookmark

Why the study?

Does intracerebroventricular administration of angiotensin II reduce renal sympathetic nerve activity in anesthetized rats?

Population

22 male Wistar rats, weighing 450-580 g, anesthetized with a mixture of urethane and alpha-chloralose…

Comparison

Intracerebroventricular administration of… vs Control injection of vehicle and/or…

Design

Preclinical

Follow-up

15-30 minutes post-injection

Authors

XJXu JinAnhui Normal University HKHiroshi KannanUniversity of Miyazaki YHYoshiaki HayashidaSaga University

Discussion

Member takes

Implication

Central AII inhibition of RSNA remains preclinical; leaves open translation to conscious models or human cardiovascular disease.

Structured PICO

Does intracerebroventricular administration of angiotensin II reduce renal sympathetic nerve activity in anesthetized rats?

Population

22 male Wistar rats, weighing 450-580 g, anesthetized with a mixture of urethane (700 mg/kg) and alpha-chloralose (70 mg/kg). Includes 6 rats with arterial baroreceptor denervation and 2 rats with bilateral transection of the cervical vagus nerves.

Intervention

Intracerebroventricular (i.c.v.) administration of angiotensin II (AII) at doses ranging from 0.01 to 100 ng (primarily 10 ng).

Comparator

Control injection of vehicle (0.9% NaCl) and/or pre-treatment with the AII antagonist saralasin (200 ng i.c.v. or 4 µg i.v.).

Outcome

Changes in renal sympathetic nerve activity (RSNA) and arterial pressure.surrogate

Central administration of angiotensin II directly inhibits renal sympathetic nerve activity via specific central receptors, independent of the baroreceptor reflex.

Limitations

Could not completely exclude the possibility that responses might be due to leakage of centrally administered AII into the systemic circulation.

Cite This Study

Jin et al. (1989) studied this question.

synapsesocial.com/papers/6a836e8ef0e941ab46b3fdf9 https://doi.org/10.7888/juoeh.11.361

View Full Paper

Ask AI

Bookmark

Inhibition of Renal Sympathetic Nerve Activity of Anesthetized Rats by Intracerebroventricular Administration of Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Inhibition of Renal Sympathetic Nerve Activity of Anesthetized Rats by Intracerebroventricular Administration of Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider