Key result
Intracerebroventricular infusion of angiotensin II in conscious sheep reduced renal sympathetic nerve activity to 38% of control at 1 nmol/h, and to 9-11% at higher doses, independent of baroreceptors.
Why the study?
Does intracerebroventricular angiotensin II alter renal sympathetic nerve activity in conscious sheep?
Population
Conscious sheep (n=5)
Comparison
Intracerebroventricular infusion of angiotensin… vs Control (baseline/pre-infusion)
Design
Preclinical
Follow-up
2 hours post-infusion
Authors
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Central ANG II suppresses RSNA via AT1 receptors in sheep; hypothesis-generating for human sympathetic control in hypertension.
Does intracerebroventricular angiotensin II alter renal sympathetic nerve activity in conscious sheep?
Intracerebroventricular angiotensin II has a direct central inhibitory action on renal sympathetic nerve activity mediated by AT-1 receptors, independent of baroreceptors.
May et al. (1997) studied this question. Intracerebroventricular angiotensin II (ANG II) vs. Control was evaluated on Efferent renal sympathetic nerve activity (RSNA). Intracerebroventricular infusion of angiotensin II in conscious sheep reduced renal sympathetic nerve activity to 38% of control at 1 nmol/h, and to 9-11% at higher doses, independent of baroreceptors.
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