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February 1, 1997AJP Regulatory Integrative and Comparative Physiology

Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep

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Population

Conscious sheep (n=6)

Comparison

Intracerebroventricular infusion of artificial… vs Intracerebroventricular hypertonic sorbitol and…

Design

Preclinical

Follow-up

20 minutes

Authors

CMClive N. MayHeart Failure & TransplantRMRobin M. McAllenThe University of Melbourne

Discussion

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Overview

No immediate clinical implications in humans; extends evidence for central AT1-mediated RSNA control in conscious sheep models.

Structured PICO

P
Population
Conscious sheep (n=6)
I
Intervention
Intracerebroventricular infusion of artificial cerebrospinal fluid (CSF) containing 0.6 M NaCl, at 1 ml/h for 20 min, with or without AT1 receptor antagonist losartan (1 mg/h)
C
Comparator
Intracerebroventricular hypertonic sorbitol (0.9 M in CSF at 1 ml/h) and control relations with intravenous phenylephrine
O
Outcome
Renal sympathetic nerve activity (RSNA)surrogate

Inhibition of renal sympathetic nerve activity by central hypertonic saline in conscious sheep is mediated by a central angiotensinergic pathway.

Cite This Study

May et al. (1997) studied this question.

synapsesocial.com/papers/6a93ee70235a0bf22c92caa3https://doi.org/10.1152/ajpregu.1997.272.2.r593
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep2004 · 51 citations
  2. 2Baroreceptor-independent renal nerve inhibition by intracerebroventricular angiotensin II in conscious sheep1997 · 47 citations
  3. 3Neural Mechanisms Subserving Central Angiotensinergic Influences on Plasma Renin in Sheep2001 · 26 citations
  4. 4Hypothalamic paraventricular nucleus mediates sodium-induced changes in cardiovascular and renal function in conscious sheep2009 · 23 citations
  5. 5Lack of interaction between a hypertonic NaCl stimulus and the brain renin-angiotensin system1983 · 21 citations