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January 1, 1989AJP Heart and Circulatory Physiology

Synergism of intraventricular NaCl infusion and subpressor angiotensins in rats

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Population

Male Wistar rats

Comparison

Intracerebroventricular infusion of hypertonic… vs Intracerebroventricular infusion of NaCl alone

Design

Preclinical

Follow-up

7 days

Authors

KKKatsutoshi KatahiraFukushima Medical UniversityHMHiroshi MikamiFukushima Medical UniversityTOToshio OgiharaNihon University

Discussion

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Overview

May not yet alter clinical practice; leaves open central NaCl-ANG II synergy for translational hypertension models.

Structured PICO

P
Population
Male Wistar rats
I
Intervention
Intracerebroventricular infusion of hypertonic NaCl (0.8 M, 1 microliter/h) concomitantly with intravenous infusion of a subpressor dose (5.4 pmol.kg-1.min-1) of angiotensin II (ANG II) or its analogues for 7 days using osmotic minipumps
C
Comparator
Intracerebroventricular infusion of NaCl alone
O
Outcome
Blood pressure (BP) change over baseline on day 7surrogate

Concomitant administration of intracerebroventricular NaCl and intravenous subpressor ANG II synergistically increases blood pressure in rats, primarily through sympathetic nerve activation.

Cite This Study

Katahira et al. (1989) studied this question.

synapsesocial.com/papers/6a90e4703ef1f7fbbf3e7886https://doi.org/10.1152/ajpheart.1989.256.1.h1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of interaction between a hypertonic NaCl stimulus and the brain renin-angiotensin system1983 · 21 citations
  2. 2Sympathetic Hyperactivity Elevates Blood Pressure During Acute Cerebroventricular Infusions of Hypertonic Sait in Rats1984 · 66 citations
  3. 3Sodium-dependent hypertension produced by chronic central angiotensin II infusion1985 · 27 citations
  4. 4Renal Neurogenic Mediation of Intracerebroventricular Angiotensin II Hypertension in Rats Raised on High Sodium Chloride Diet1997 · 36 citations
  5. 5NaCl injections in brain induce natriuresis and blood pressure responses sensitive to ANG II AT1 receptors1995 · 29 citations