Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1995AJP Renal Physiology

NaCl injections in brain induce natriuresis and blood pressure responses sensitive to ANG II AT1 receptors

View Full Paper
Ask AI
Bookmark
Share

Population

Conscious Wistar rats

Design

Preclinical

Authors

PRPeter RohmeissUniversity of MannheimCBChristian BeyerSwiss Center for Electronics and Microtechnology (Switzerland)ÉNÉva NagyRoyal North Shore Hospital

Discussion

Loading...

Member takes

Overview

Losartan effects in this rat model should not inform clinical practice; leaves open central AT1 receptor involvement in human volume regulation.

Structured PICO

P
Population
Conscious Wistar rats
I
Intervention
Intracerebroventricular (icv) bolus injections of hypertonic saline (0.19, 0.23, 0.30, and 0.60 M; 5 microliters) with or without pretreatment with losartan (5 micrograms icv)
O
Outcome
Renal sodium excretion and mean arterial blood pressure (MAP)surrogate

Central angiotensinergic mechanisms via AT1 receptors are involved in the natriuretic and pressor responses to intracerebroventricular hypertonic saline in rats.

Cite This Study

Rohmeiss et al. (1995) studied this question.

synapsesocial.com/papers/6a8c2ecf77493d51bfdeffddhttps://doi.org/10.1152/ajprenal.1995.269.2.f282
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osmotically induced natriuresis and blood pressure response involves angiotensin AT1 receptors in the subfornical organ1995 · 33 citations
  2. 2Synergism of intraventricular NaCl infusion and subpressor angiotensins in rats1989 · 19 citations
  3. 3Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep1997 · 32 citations
  4. 4Sympathetic Hyperactivity Elevates Blood Pressure During Acute Cerebroventricular Infusions of Hypertonic Sait in Rats1984 · 66 citations
  5. 5Lack of interaction between a hypertonic NaCl stimulus and the brain renin-angiotensin system1983 · 21 citations