Key result
Microinjection of 4% hypertonic saline into the nucleus tractus solitarii of conscious rats increased mean blood pressure to 155 mmHg compared to 119 mmHg with dextrose (P<0.05).
Population
Conscious rats
Comparison
Microinjection of hypertonic saline 4% into the… vs Equiosmolar dextrose solution microinjection or…
Design
Preclinical
Authors
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NTS hypertonicity may drive sympathetic hypertension in conscious models; extends anesthetized data but leaves clinical translation open.
Absolute Event Rate: 155% vs 119%
p-value: p=<0.05
Microinjection of hypertonic saline into the NTS of conscious rats elicits a hypertensive response primarily due to acute stimulation of central sympathetic neurons.
Vlahakos et al. (1988) studied Conscious rats. Hypertonic saline microinjection into the nucleus tractus solitarii vs. Equiosmolar dextrose solution or cannula only was evaluated on Mean blood pressure (p=<0.05). Microinjection of 4% hypertonic saline into the nucleus tractus solitarii of conscious rats increased mean blood pressure to 155 mmHg compared to 119 mmHg with dextrose (P<0.05).
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