Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1983AJP Heart and Circulatory Physiology

Lack of interaction between a hypertonic NaCl stimulus and the brain renin-angiotensin system

View Full Paper
Ask AI
Bookmark
Share

Population

Morphine-pentobarbital-anesthetized dogs with both vagus and carotid sinus nerves cut

Comparison

Intraventricular injection of 0.6 M NaCl before… vs Baseline responses before brain RAS blockade

Design

Preclinical

Authors

STShuichi TakishitaKagoshima UniversityCFCarlos M. FerrarioPreventive Cardiology

Discussion

Loading...

Member takes

Overview

Central hypertonic NaCl activates sympathetic outflow independently of brain ANG II in this canine model; hypothesis-generating for salt-sensitive hypertension mechanisms.

Structured PICO

P
Population
Morphine-pentobarbital-anesthetized dogs with both vagus and carotid sinus nerves cut (baroreceptor-denervated)
I
Intervention
Intraventricular (IVT) injection of 0.6 M NaCl before and after blockade of the brain RAS with either captopril or [Sar1,Ile8]ANG II
C
Comparator
Baseline responses before brain RAS blockade
O
Outcome
Postganglionic renal nerve activity (RNA) and blood pressuresurrogate

Central administration of hypertonic NaCl in baroreceptor-denervated dogs activates sympathetic nerve activity independently of the brain renin-angiotensin system.

Cite This Study

Takishita et al. (1983) studied this question.

synapsesocial.com/papers/6a901b22b71d06dae589d3fchttps://doi.org/10.1152/ajpheart.1983.244.4.h471
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurohormonal characteristics of cardiovascular response due to intraventricular hypertonic NaCl1984 · 58 citations
  2. 2Synergism of intraventricular NaCl infusion and subpressor angiotensins in rats1989 · 19 citations
  3. 3Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep1997 · 32 citations
  4. 4Differential sympathetic responses initiated by angiotensin and sodium chloride1983 · 50 citations
  5. 5Role of vasopressin in cardiovascular and neurohormonal responses to intracerebroventricular hypertonic NaCl.1990 · 7 citations