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July 1, 1983AJP Regulatory Integrative and Comparative Physiology

Differential sympathetic responses initiated by angiotensin and sodium chloride

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Population

Anesthetized, sinoaortic denervated, vagotomized cats

Design

Preclinical

Authors

JTJean C. TobeyUniversity of SaskatchewanHFHildburg FryFederal Institute for Risk AssessmentCMC. S. Mizejewski

Discussion

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Implication

Differential sympathetic patterns in animals are hypothesis-generating; leaves open mechanisms of pressor effects with no clinical implications.

Structured PICO

P
Population
Anesthetized, sinoaortic denervated, vagotomized cats
I
Intervention
Intracarotid and intracerebroventricular (icv) injection of Angiotensin II (ANG II) and hypertonic NaCl
O
Outcome
Changes in splenic and renal sympathetic nerve activitysurrogate

Central stimulation by angiotensin II and sodium chloride produces differential sympathetic nerve responses, which may mediate their complex cardiovascular pressor effects.

Cite This Study

Tobey et al. (1983) studied this question.

synapsesocial.com/papers/6a81642b046b5fb0cc649ceehttps://doi.org/10.1152/ajpregu.1983.245.1.r60
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