September 1, 1997Hypertension

Renal Neurogenic Mediation of Intracerebroventricular Angiotensin II Hypertension in Rats Raised on High Sodium Chloride Diet

View Full Paper

Ask AI

Bookmark

Why the study?

Does elevated postnatal NaCl intake enhance the pressor sensitivity of the brain to Ang II in rats?

Population

Sprague-Dawley rats raised from 2 to 3 weeks of age on low, normal, or high NaCl diets, and 10-week-old rats…

Comparison

Intracerebroventricular angiotensin II infusion… vs Artificial cerebrospinal fluid infusion during…

Design

Preclinical

Follow-up

5 days

Authors

JOJeffrey L. OsbornUniversity of Southern California ACAmadou K.S. CamaraMedical College of Wisconsin

Discussion

Member takes

Implication

Renal nerves mediate high-sodium programmed central Ang II hypertension in rats; hypothesis-generating for human salt-sensitive mechanisms.

Structured PICO

Does elevated postnatal NaCl intake enhance the pressor sensitivity of the brain to Ang II in rats?

Population

Sprague-Dawley rats raised from 2 to 3 weeks of age on low (5.0 mmol/L per kg food), normal (50 mmol/L per kg food), or high (250 mmol/L per kg food) NaCl diets, and 10-week-old rats exposed to a high sodium diet for 2 weeks.

Intervention

Intracerebroventricular (I.C.V.) angiotensin II (Ang II) infusion (20 ng/min) for 5 days, with or without bilateral renal denervation.

Comparator

Artificial cerebrospinal fluid infusion (0.25 microL/min I.C.V.) during control and recovery.

Outcome

Mean arterial pressure and sodium excretion/retention over 5 days.surrogate

Elevated postnatal sodium intake enhances the pressor sensitivity of the brain to angiotensin II in rats, a response dependent on intact renal nerves.

Cite This Study

Osborn et al. (1997) studied this question.

synapsesocial.com/papers/6a7e6604760ccf6bd0991310 https://doi.org/10.1161/01.hyp.30.3.331

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Renal nerves mediate high-sodium programmed central Ang II hypertension in rats; hypothesis-generating for human salt-sensitive mechanisms.

Renal Neurogenic Mediation of Intracerebroventricular Angiotensin II Hypertension in Rats Raised on High Sodium Chloride Diet

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renal Neurogenic Mediation of Intracerebroventricular Angiotensin II Hypertension in Rats Raised on High Sodium Chloride Diet

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider