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June 1, 2001Hypertension

Neural Mechanisms Subserving Central Angiotensinergic Influences on Plasma Renin in Sheep

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Key result

ICV angiotensin II reduces plasma renin ~63%, an effect blocked by losartan and renal denervation.

Population

Sodium-depleted sheep, including models with lamina terminalis ablation, median eminence lesions, or…

Design

Preclinical

Follow-up

up to 2.5 hours (1 hour infusion plus 90 minutes)

Authors

MMM. J. McKinleyThe University of MelbourneMMM. McBurnieThe University of MelbourneMMMichael L. MathaiVictoria University

Discussion

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Implication

Does not inform clinical hypertension care; leaves open translation of lamina terminalis AT1–renal nerve pathways to humans.

Structured PICO

P
Population
Sodium-depleted sheep undergoing intracerebroventricular infusions and brain lesions to study plasma renin regulation.
I
Intervention
Intracerebroventricular (ICV) infusion of angiotensin II (3 microg/h for 1 hour), losartan (1 mg/h), or hypertonic NaCl (0.75 mol/L at 1 mL/h)
O
Outcome
Plasma renin concentrationsurrogate

Main Result

Absolute Event Rate: 1.6% vs 4.3%

Central AT1 receptors in the lamina terminalis mediate angiotensin II-induced suppression of renin secretion via reduction in renal sympathetic nerve activity.

Cite This Study

McKinley et al. (2001) studied Sodium-depleted sheep. Intracerebroventricular (ICV) infusion of angiotensin II vs. Baseline was evaluated on Plasma renin concentration. Intracerebroventricular infusion of angiotensin II reduced plasma renin concentration from 4.3 to 1.6 pmol angiotensin I/mL per hour, an effect blocked by losartan and renal denervation.

synapsesocial.com/papers/6aa35a71fd19ae9969b1417dhttps://doi.org/10.1161/01.hyp.37.6.1375
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baroreceptor-independent renal nerve inhibition by intracerebroventricular angiotensin II in conscious sheep1997 · 47 citations
  2. 2Role of Nitric Oxide in the Attenuated Pressor Responses of Pregnant or Sodium-Deplete Sheep1996 · 7 citations
  3. 3Interhippocampal Impulses1960 · 84 citations
  4. 4Renal denervation does not prevent dehydration‐induced natriuresis in sheep1989 · 15 citations
  5. 5Effect of individual or combined ablation of the nuclear groups of the lamina terminalis on water drinking in sheep1999 · 76 citations