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May 13, 2004AJP Regulatory Integrative and Comparative Physiology

Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep

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Why the study?

Does central administration of angiotensin II increase cardiac sympathetic nerve activity in conscious sheep?

Population

Conscious sheep with implanted electrodes (n=5)

Comparison

Intracerebroventricular infusions of ANG II and… vs Intracerebroventricular artificial cerebrospinal…

Design

Preclinical

Follow-up

30 minutes

Authors

AWAnna M.D. WatsonBaker Heart and Diabetes InstituteRMRasim MoğulkoçSelçuk UniversityRMRobin M. McAllenThe University of Melbourne

Discussion

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Overview

Central AT1 activation augments CSNA in sheep; hypothesis-generating for human sympathetic regulation in hypertension.

Structured PICO

Does central administration of angiotensin II increase cardiac sympathetic nerve activity in conscious sheep?

P
Population
Conscious sheep with implanted electrodes (n=5)
I
Intervention
Intracerebroventricular infusions of ANG II (3 nmol/h for 30 min) and hypertonic saline (0.6 M NaCl in CSF at 1 ml/h), with or without intracerebroventricular losartan (1 mg/h)
C
Comparator
Intracerebroventricular artificial cerebrospinal fluid (CSF) (1 ml/h)
O
Outcome
Cardiac sympathetic nerve activity (CSNA) and mean arterial pressure (MAP)surrogate

Central angiotensin acts via AT-1 receptors to increase cardiac sympathetic nerve activity despite increased arterial pressure, potentially explaining the blunted bradycardia response to acute pressor effects.

Cite This Study

Watson et al. (2004) studied this question.

synapsesocial.com/papers/6a19b09b3f3ec013f0deed60https://doi.org/10.1152/ajpregu.00708.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep1997 · 32 citations
  2. 2Central Action of Angiotensin and Hypertension : Increased Central Vasomotor Outflow by Angiotensin1972 · 37 citations
  3. 3Neurohumoral contributions to chronic angiotensin-induced hypertension1986 · 35 citations
  4. 4Central gain of the cardiac sympathetic afferent reflex in dogs with heart failure1997 · 75 citations
  5. 5Inhibition by angiotensin II of baroreceptor‐evoked activity in cardiac vagal efferent nerves in the dog.1979 · 199 citations