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November 1, 1996Clinical and Experimental Pharmacology and Physiology

Prolonged Systemic and Regional Haemodynamic Effects of Intracerebroventricular Angiotensin Ii in Conscious Sheep

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Why the study?

Does intracerebroventricular angiotensin II cause different regional haemodynamic effects compared to intravenous angiotensin II in conscious sheep?

Population

Conscious sheep fitted with flow probes for measurement of cardiac output and coronary, mesenteric, renal…

Comparison

Intracerebroventricular Angiotensin II vs Intravenous Angiotensin II

Design

Preclinical

Follow-up

Up to 3 hours post-infusion

Authors

CMClive N. May

Discussion

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Overview

Contrasting central-peripheral AngII responses in sheep extend preclinical models; leaves open human translation and should not change practice.

Structured PICO

Does intracerebroventricular angiotensin II cause different regional haemodynamic effects compared to intravenous angiotensin II in conscious sheep?

P
Population
Conscious sheep fitted with flow probes for measurement of cardiac output and coronary, mesenteric, renal and iliac blood flows
I
Intervention
Intracerebroventricular (i.c.v.) Angiotensin II (10 nmol/h for 1 h)
C
Comparator
Intravenous (i.v.) Angiotensin II (5, 10, 25, 50 nmol/h)
O
Outcome
Arterial pressure and regional haemodynamic changes (cardiac output, coronary, mesenteric, renal, and iliac blood flows)surrogate

Central and peripheral administration of angiotensin II produce contrasting regional haemodynamic responses in conscious sheep, with central administration causing prolonged pressor effects mainly via mesenteric vasoconstriction.

Cite This Study

Clive N. May (1996) studied this question.

synapsesocial.com/papers/6a90f3fe504d7cdc493e7fffhttps://doi.org/10.1111/j.1440-1681.1996.tb01137.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dose-response study of the redistribution of intravascular volume by angiotensin II in man1992 · 25 citations
  2. 2Mechanism of Suppression of Plasma Renin Activity by Centrally Administered Angiotensin II*1979 · 45 citations
  3. 3Plasma Renin Activity Following Central Infusion of Angiotensin II and Altered CSF Sodium Concentration in the Conscious Goat1976 · 36 citations
  4. 4Angiotensin II attenuates baroreflex control of heart rate and sympathetic activity1984 · 181 citations
  5. 5The action of angiotensin II on the baroreflex response of the conscious ewe and the conscious fetus.1979 · 108 citations