Key result
Intracerebroventricular infusion of losartan significantly reduced elevated cardiac sympathetic nerve activity (from 88±3 to 69±5 bursts per 100 heart beats) in an ovine model of heart failure.
Why the study?
Does central intracerebroventricular infusion of losartan reduce cardiac sympathetic nerve activity in an ovine model of heart failure?
Population
Conscious normal sheep and sheep with heart failure induced by rapid ventricular pacing
Comparison
Intracerebroventricular infusion of losartan vs Normal sheep receiving the same infusion, and…
Design
Preclinical
Follow-up
5 hours
Authors
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No immediate clinical implications; extends preclinical evidence for central AT1 blockade in ovine HF.
Does central intracerebroventricular infusion of losartan reduce cardiac sympathetic nerve activity in an ovine model of heart failure?
Absolute Event Rate: 69% vs 88%
Central angiotensin type 1 receptor blockade with losartan reduces elevated cardiac sympathetic nerve activity in an ovine model of heart failure, indicating a critical role for central angiotensin receptors.
Ramchandra et al. (2012) studied Heart failure. Intracerebroventricular infusion of losartan vs. Normal animals / baseline was evaluated on Cardiac sympathetic nerve activity (CSNA). Intracerebroventricular infusion of losartan significantly reduced elevated cardiac sympathetic nerve activity (from 88±3 to 69±5 bursts per 100 heart beats) in an ovine model of heart failure.
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